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Our Portfolio

We have invested in 50+ companies across all industries and are growing.

Company Type

All
Biotech
Consumer
Enterprise

3DR

Amper Music

Appia Bio

Bark

Boundless

Brella

Canary

Candu

CapSen

Carbon Health

Castor

Comet

Compound Eye

CoverWallet

Cylera

Dextro

Dorsal

Dynasty

Eave

Enigma

Experiment

Firedome

Flatfile

Floored

GitLab

Glide

Hexagon Bio

Homer Logistics

InsightSquared

insitro

Kallyope

Kasisto

Kickboard

littleBits

Lytics

Mesosphere

Message.io

Mirantis

NewtonX

NS1

Odeko

Per Diem

Placed

Play Impossible

Pro.com

Pryon

Radar

RapidSOS

Recursion Pharmaceuticals

Remote

Renthop

Replicated

RockPaperRobot

Security Scorecard

Socure

Spell

Spruce Up

Suplari

Switchboard

Terbium Labs

Terray Therapeutics

Text Blaze

Theorem

Timescale

Tinybop

Tive

Trustology

UMA

Verge Genomics

Wealthsimple

WHOOP

x.ai

Xilis

Zymergen

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Two Sigma is proud to be an equal opportunity workplace. We do not discriminate based upon race, religion, color, national origin, sex, sexual orientation, gender identity/expression, age, status as a protected veteran, status as an individual with a disability, or any other applicable legally protected characteristics.

Two Sigma and the Two Sigma logo are trademarks of Two Sigma Investments, LP. Beaker® is a registered trademark of Two Sigma Open Source, LLC.

The portfolio companies shown in Our Portfolio represent substantially all of Two Sigma Ventures’ investment history in companies as of July 09, 2021. Certain portfolio companies have been excluded in which Two Sigma does not have permission to disclose publicly or no longer holds an interest and have either liquidated or gone bankrupt. It should not be assumed that the investment in the portfolio companies identified was or will be profitable. For a full list of Two Sigma Ventures investments, please click here. Excluded from the list of Two Sigma Ventures Investments are investments for which the issuer has not provided permission for Two Sigma Ventures to disclose publicly.

This website is intended solely to provide general information about Two Sigma Ventures, its services to entrepreneurs, and its people. This website is not an offer to, or solicitation of, any potential clients or investors for the provision by Two Sigma of investment management, advisory or any other related services. No material listed on this website is or should be construed as investment advice, nor is anything on this website an offer to sell, or a solicitation of an offer to buy, any security or other instrument. Links from this website to third-party websites do not imply any endorsement by the third party of this website or of the link; nor do they imply any endorsement by this firm of the third-party website or of the link.

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Kallyope

Kallyope is a platform biotechnology company dedicated to unlocking the therapeutic potential of the gut-brain axis. Their cross-disciplinary team integrates cutting-edge technologies in sequencing, bioinformatics, neural imaging, cellular and molecular biology, and human genetics to provide an understanding of gut-brain biology that will lead to transformational therapeutics to improve human health. The company’s founders are Charles Zuker, Ph.D., Lasker Award winner Tom Maniatis, Ph.D., and Nobel laureate Richard Axel, M.D.