We Invest In

Technology that unlocks
human potential
Platforms to discover
breakthrough therapies
Artificial intelligence to
enable human interaction
Technology that connects
people around the world
Software that's built
to protect kids online

What We Do

We believe the world is changing faster than ever.

We are an early-stage venture capital firm investing in transformative companies harnessing information growth and computing power to change the world.

We believe the most important companies of the future will be the product of three forces: the exponentially increasing availability of information; rapid advancements in the science of computing; and the ingenuity of visionary founders.

We have seen the information + computing + people thesis transform the business of investment management, and we support companies applying it to other industries.

Our Values

Our Values


We believe we are stronger as a collective than as individuals, and look for every opportunity to augment our own abilities with the resources and expertise around us.


We are humble enough to acknowledge that which we cannot know or predict, and remain diligently focused on our search for knowledge and understanding.


We endeavor to understand and respect the ambitions and challenges of entrepreneurs, and do all we can to support them as they work to achieve their objectives.


We earnestly challenge the status quo and are ambitious in our efforts to improve upon it through the discovery and creation of technological breakthrough.

Our Focus

We support companies using data science and advanced engineering to create the future.

Early stage

We invest early—from seed to series B—and stick around as a long-term partner.

Across industries

From infrastructure tools and healthcare to real estate and consumer hardware, we support data- and computing-driven transformation in every industry.

Where we have expertise

We bring Two Sigma brainpower in software engineering, data science, quantitative modeling, machine learning and more to all we do.

How We Help

We have deep expertise and an extensive technical network.

Throughout 15+ years of building Two Sigma, we’ve learned a lot about what makes a technology company succeed. Though we can hardly be called a startup anymore, our team and the over 1,600 employees and 200 PhDs we’re lucky to call colleagues bring a wealth of extraordinary experience to every company we work with.

Our Portfolio

We have invested in 50+ companies and growing.

Zymergen uses data, machine learning, automation, and software tools to unlock the power of biology through technology.


CoverWallet is an online platform that offers insurance-management services to its clients.


Enigma takes the mystery out of open-source public data, providing analysis tools that collect, curate, and mine public government information and available research information for insight.


Snapshot of Enigma Program

NS1 is an intelligent domain name system (DNS) and traffic-management platform that uses a data-driven architecture to make routing decisions in real-time.


Snapshot of NS1 program

Placed provides real-world insights to brands and advertisers by measuring and analyzing what its opt-in panel of smartphone customers likes, where they are, and what they like to do.


Snapshot of Placed program

x.ai is an artificial-intelligence-driven personal assistant that combines machine learning and human intelligence to schedule meetings.


Snapshot of Xai Program

Our Team

We are data scientists, engineers, entrepreneurs & operators.

Our core team is dedicated to finding and partnering with great founders. We are supported by Venture Partners who bring years of experience building Two Sigma, and an army of experts from Two Sigma who are eager to share their skills.