We Invest In

Technology that unlocks
human potential
Platforms to discover
breakthrough therapies
Artificial intelligence to
enable human interaction
Technology that connects
people around the world
Software that's built
to protect kids online

What We Do

We believe the world is changing faster than ever.

We are an early-stage venture capital firm investing in transformative companies harnessing information growth and computing power to change the world.

We believe the most important companies of the future will be the product of three forces: the exponentially increasing availability of information; rapid advancements in the science of computing; and the ingenuity of visionary founders.

We have seen the information + computing + people thesis transform the business of investment management, and we support companies applying it to other industries.

Our Values

Our Values

SMARTER TOGETHER

We believe we are stronger as a collective than as individuals, and look for every opportunity to augment our own abilities with the resources and expertise around us.

HUMBLY OPEN-MINDED

We are humble enough to acknowledge that which we cannot know or predict, and remain diligently focused on our search for knowledge and understanding.

EMPATHETIC

We endeavor to understand and respect the ambitions and challenges of entrepreneurs, and do all we can to support them as they work to achieve their objectives.

CHALLENGING CONVENTION

We earnestly challenge the status quo and are ambitious in our efforts to improve upon it through the discovery and creation of technological breakthrough.

Our Focus

We support companies using data science and advanced engineering to create the future.

Early stage

We invest early—from seed to series B—and stick around as a long-term partner.

Across industries

From infrastructure tools and healthcare to real estate and consumer hardware, we support data- and computing-driven transformation in every industry.

Where we have expertise

We bring Two Sigma brainpower in software engineering, data science, quantitative modeling, machine learning and more to all we do.

How We Help

We have deep expertise and an extensive technical network.

Throughout 15+ years of building Two Sigma, we’ve learned a lot about what makes a technology company succeed. Though we can hardly be called a startup anymore, our team and the over 1,600 employees and 200 PhDs we’re lucky to call colleagues bring a wealth of extraordinary experience to every company we work with.

Our Portfolio

We have invested in 90+ companies and growing.

Recursion Pharmaceuticals combines experimental biology, automation, and artificial intelligence in a massively parallel system to quickly and efficiently identify treatments for diseases utilizing massive, data-rich image sets generated in house.

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CoverWallet is an online platform that offers insurance-management services to its clients.

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Carbon Health makes smart, hassle-free healthcare accessible to all.

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WHOOP develops wearable technology that enables athletes, trainers, and coaches to optimize performance based on heart rate and movement data.

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insitro aims to integrate cutting-edge machine learning techniques with the ground-breaking innovations that have occurred in life sciences that enable the creation of the large, high-quality data sets.

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Our Team

We are data scientists, engineers, entrepreneurs & operators.

Our core team is dedicated to finding and partnering with great founders. We are supported by Venture Partners who bring years of experience building Two Sigma, and an army of experts from Two Sigma who are eager to share their skills.